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KMID : 1098420120200010008
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Korean Journal of Medicinal Crop Science
2012 Volume.20 No. 1 p.8 ~ p.15
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Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice
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Jung Myung-Hwan
Song Kyung-Sik
Seong Yeon-Hee
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Abstract
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The present study investigated an ethanol extract of Chaenomeles sinensis fruit (CSF) for possible neuroprotective effects on neurotoxicity induced by amyloid β protein (Aβ) (25-35) in cultured rat cortical neurons and also for antidementia activity in mice. Exposure of cultured cortical neurons to 10 μM Aβ (25-35) for 36 h induced neuronal apoptotic death. At 0.1-10 ㎍/㎖, CSF inhibited neuronal death, elevation of intracellular calcium concentration ([Ca2+]i), and generation of reactive oxygen species (ROS) induced by Aβ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of mice with 15 nmol Aβ (25-35) was inhibited by chronic treatment with CSF (10, 25 and 50 ㎎/㎏, p.o. for 7 days) as measured by a passive avoidance test. CSF (50 ㎎/㎏) inhibited the increase of holinesterase activity in Aβ (25-35)-injected mice brain. From these results, we suggest that the antidementia effect of CSF is due to its neuroprotective effect against Aβ (25-35)-induced neurotoxicity and that CSF may have a therapeutic role for preventing the progression of Alzheimer’s disease.
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KEYWORD
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Chaenomeles sinensis Fruit, Neuroprotection, Amyloid ${\beta}$ 수식 이미지 Protein, Cultured Neurons, Memory Impairment
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